Cortical and Subcortical Electrical Activity in Experimental Seizures Induced by Metrazol
نویسندگان
چکیده
منابع مشابه
Cortical and subcortical electrical activity in experimental seizures induced by metrazol.
The convulsant drug, metrazol, has long been known to produce experimelltal seizures of the grand ma1 type and, more recently, has been employed clinically, either in shock therapy for patients with mental disease (11) or as an aid in the diagnosis of suspected epilepsy (2, 3, 8, 12, 16). Administration of ~ubconvuls i~~ doses of metrazol has been used to provoke abnormal discharge in the elect...
متن کاملCortical deactivation induced by subcortical network dysfunction in limbic seizures.
Normal human consciousness may be impaired by two possible routes: direct reduced function in widespread cortical regions or indirect disruption of subcortical activating systems. The route through which temporal lobe limbic seizures impair consciousness is not known. We recently developed an animal model that, like human limbic seizures, exhibits neocortical deactivation including cortical slo...
متن کاملIron-induced experimental cortical seizures: Electroencephalographic mapping of seizure spread in the subcortical brain areas
The iron-induced model of post-traumatic chronic focal epilepsy in rats was studied by depth-electrode mapping to investigate the spread of epileptiform activity into subcortical brain structures after its onset in the cortical epileptic focus. Electrical seizure activity was recorded in the hippocampal CA1 and CA3 areas, amygdala and caudate-putamen, in rats with iron-induced chronic cortical ...
متن کاملhydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction
hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...
Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice
Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor) on seizure models induced by pentylenetetrazol (PTZ) and maximal electroshock stimulation (MES). Methods: Totally, 260 mice were ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 1953
ISSN: 0022-3069,1554-6578
DOI: 10.1097/00005072-195307000-00006